They discuss the common issues and practices in creating a framework, the pros & cons of using web frameworks, a comparison of LESS & SASS, and the responsibility in supporting each product's fast growing user base. It was interesting to learn that they both are pretty normal guys and worked together at Zurb.
Watch the video
About Cascade SF
Cascade SF is an organization dedicated to teaching the latest tips, tricks, and techniques in web design. Their events cover everything from user experience design, to interface designs, design theory, content strategy, mobile application design, HTML5, CSS3, and JS. Check out videos from past events.
On a side note, Mark Otto's voice and jokes remind me of Seth Rogen.